Ultra-fast screening by Raman imaging RAMANview


RAMANview, the wide-field Raman microscope has changed the common knowledge of space scaling of Raman imaging. A brand new world of application has been broadened.

药片的高速拉曼成像分析

药片表面有1mm左右高低差的成像正是RAMANview擅长之处。 大约 1cm 大小的拉曼成像,只需要 14 分钟就能取得。 如果使用0.5倍的镜头,焦深更长,也能取得药片侧面的成像。


測定条件(左)
激光波长
532 nm
物镜
1x
画素数
202 x 202 pixel
测定时间
14 min

測定条件(右)
激光波长
532 nm
物镜
0.5x
画素数
99 x 192 pixel
测定时间
8 min

弧形药片的正面和侧面的高速拉曼成像

Acetaminophen Ethenzamide Anhydrous caffeine
Φ10.5mm ΔH1.1mm
测量封装好的药片也 OK !

因为无法把包装内的药片的表面削平,而且因为在包装内药片无法固定,有一点振动就易摇晃。 这给测量造成不便。但是 RAMANview 具有长焦深和激光束扫描的优势,在这种条件下测量也是没有问题的。

激光波长
532 nm
物镜
1x
画素数
202 x 202 pixel
测定时间
14 min

Highly precise Raman imaging analysis of tablet

进行成分组成细致观测时,推荐使用高清成像模式。 右边的数据是,两种解热镇痛剂表面的高精细拉曼成像数据。 与高速成像模式相比虽然测量速度下降,但能清晰地观测到大范围的成分组成。 对于含量少的成分,粒径也能分析。 因为每个粒子都接近椭圆,所以能计算出长边和短边的柱状图。

对比 2 种消热镇痛药的高精细拉曼成像

Acetaminophen Ethenzamide Caffeine
Allyl isopropyl acetyl urea

Tablet A 52%
28%
12%
-
Tablet B
19% 48% 10% 7%
 
药片中的咖啡因粒径分析(药片 A 和 B 的比较)
椭圆率的柱状图
面积的柱状图

Detect 1% API among the pharmaceutical formulation content

This shows the component distribution of a tablet. RAMANview's 2x objective lens is able to detect the slight amount of APIs (0.5mg) during solid dosage form by means of both a high spatial resolution and wide-area scanning.

Analysis of powder inside a plastic bag

The deep depth of focus is a great tool for bulky samples, however, even an analysis inside thin plastic bags are greatly performed with RAMANview. Raman peaks from thin film, which can be a noise for micro-Raman system, are not included in a spectrum obtained by RAMANview.

Analysis of crystallinity distribution of resin molded product

The FWHM of polyethylene terephthalate's peak at around 1720cm-1 changes due to the degree of crystallinity. The image above visualizes the difference in the degree of crystallinity from the mouth to the body part of PET bottle.

Observation of the composition distribution of Inada granite's surface

The red, blue and green parts are known as quartz, biotite and feldspar respectively from the Raman spectrum. Deterioration and erosion of the rock can be captured with a centimeter-order field-of-view by RAMANview.※This sample is provided by Professor Satoru Nakajima of Osaka University.

Observation of the distribution of SiC crystal polymorphism

This shows the distribution of polymorphic changes from 4H to 6H of a SiC crystal surface. RAMANview, equipped with wide field-of-view objective lens and fast laser beam scanning, is the best analytical tool for the analysis of the polytypic distribution over a wide range in just 10 minutes.

Crystal quality analysis of diamond

It is an analysis example of diamond file. Diamond has a sharp peak at 1330cm-1, whereas amorphous carbon which is an artificial diamond has a broad peak. It is also applicable to analysis of large-area DLC film.